The world has entered a new stage of transition from COVID-19 as pandemic to endemic. Many countries in the world decided to loosen the health restriction and more adaptable with prevention of the outbreak, as if it normal disease like any other illness. Despite the efforts attempted to return to the new normal, the challenges remain. The global recessions, pandemy, high inflation rate, food crisis, water and medical shortages, Russian invasions, economic pressure, energy crisis, the US-China geopolitical rivalry, Islamophobia, territorial disputes, Palestinian questions, terrorism and cyber security are among the issues often addressed as global focus without ignoring the possibility of new challenges might arise.