Agam is one of  filariasis endemic areas in the West sumatera, it need mass treatment. TAS survey obtained 7.7% of elementary school students positively infected filarial after 6 year  mass treatment. Data of medication coverage were not fulfill the target of 85%. These results indicate that interventions for health cadres is necesery. Health cadres   have role in the distribution and socialization at mass treatment on filariasis prevention. Aims this intervention is increasing public compliance  taking a medications. This research use Mix-Methode (quantitative and qualitative) approach  with quasi-experimental before-after control design to health cadres and the qualitative research  with in-depth interviews to determine the existence of social capital at mass treatment on filariasis prevention. Assessment of medication coverage by cross-sectional. Results show that there was an increasing of cadre’s knowledge as much as 26.8% after refreshing program (p value = 0.001). Attitude has increased, but statistically not significant (p value = 0.201). Results of in-depth interviews revealed that there was social capital in the socialization and motivation at mass treatment on filariasis prevention. Medication adherence in the intervention area (18.9%) more increasing then in the  control area (13.1%) p-value of 0.001 in intervention area and 0,093 in control. There was an increasing in knowledge and attitudes after the intervention. The existence of social capital in efforts  improvement medication adherence and  increasing in medication adherence in the study area. Department of Health at Agam district should  take  advantage of social capital that was growing up in the community  to in efforts increasing the medication coverage..

Keywords: Social capital, filariasis, medication adherence.