Since it was first identified in Indonesia in March 2020, the spread of the Covid-19 virus has continued to expand, especially in big cities with high population density and mobility levels. The population and economic growth of Surakarta has caused the spread of the virus among its residents to be very rapid. This worrying condition has triggered the local government to implement various policies that are expected to reduce the spread of the virus, ranging from cutting the operating hours of activity centers (entertainment centers, shopping centers, places of worship, etc.), mudik-bans, to accelerating vaccinations among its citizens. To see the effect of implementing policies related to Covid-19 on the spatial pattern of positive cases in Surakarta, a study on the spatio-temporal distribution of positive cases of Covid-19 was conducted. The study was conducted by utilizing correlational and spatial descriptive analysis that took the temporal data of positive cases, the distribution of activity centers, and the Covid-19 related policies implementation period into account. The results of this study indicate that the spatial pattern of positive Covid-19 cases in Surakarta has a close relationship with the distribution of activity centers. In addition, the implementation of policies related to Covid-19 affected the number of positive cases of Covid-19 in Surakarta, where the number was high at the beginning of the pandemic, decreased slightly when the mudik-ban was imposed, and decreased further after citizens vaccination was carried out.