Introduction: Nurses have responsibility in reducing the transmission of tuberculosis within family environment, but the progress is considered not optimal due to health team’s limitation in number and ability. This study aimed to determine the relationship between nurse performance and tuberculosis preventive efforts carried out by families in Gorontalo City. Method: A cross sectional design with purposive sampling was applied. The sample size were 155 families and 6 nurses from 6 Public Health Centre with ‘madya’ accredited at Gorontalo. It applied univariate and bivariate chi square analysis. Results: The results showed that families mostly have basic educational background (44.6%), nurses’ performance was good (56.1%), families’ ability to prevent TB disease (54.2%), nurses who have more than 10 years working experience (83.3%) and with diploma nursing background (66.7%).  There was a relationship between nurse performance and preventive efforts for pulmonary tuberculosis in Gorontalo City (P Value=0.000). Conclusion: Nurses’ performance is important in optimizing the family ability to do TB preventive efforts. These are the way to reduce and control TB transmission in the family sphere. Therefore, nurses at Public Health Centre need to maintain good performance in providing care.

Keywords: prevention of transmission, nursing, family role, tuberculosis, nurse performance