Lili Amelia¹, , Mahdi Jufri² Abdul Mun’im³

¹Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

²Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

³Laboratory of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia

Abstract

Nothopanax scutellarium Merr. is one of plant that have several advantage such as obstetrics, kidney disease, inflamantory disease, and promotion of hair growth. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal drug delivery of drugs. Ethosomes have higher penetration rate through skin. It contain soft vesicle, composed of hydroalcoholic or hydroglycolic phospholipid in which concentration of alcohol is relatively high. Ethosomes are novel carrier for enhanced skin delivery. The aims of this research were to formulate and obtain ethosome characteristic which formed by thin layer hydration method. The formulation of ethosome that using 20% ethanol,  and the ratio of phosphatidylcholine and ethyl acetate fraction were 1:2. The characterization from the ethosome suspension indicated that the entrapment efficiency value 82,135%  with particle size distribution value (Z-Avarage) 110,5 nm, polidispersity index (PdI) 0,393 and zeta potential value -11,0  mV.

Keywords: Nothopanax scutellarium Merr, delivery system, ethosome, characterization