Universitas Indonesia Conferences, Asian Federation for Pharmaceutical Sciences (AFPS) 2019

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Comparison of Serum OxLDL-Beta2glycoprotein I Complexes in Type 2 Diabetes Mellitus Patients with Estimated Glomerular Filtration Rate >= 90 and 60-89 mL/min/1,72 m2
Afina Irsyania Zulfa, Rani Sauriasari, Azizahwati Azizahwati

Last modified: 2019-07-18


Background: Glomerular lesions in diabetic nephropathy can develope even under normoalbuminuria conditions which resulted glomerular hyperfiltration in early stage. One of oxidative stress marker is oxLDL-β2glycoprotein I complexes that participated in glomerulosclerosis and interstitial fibrosis. Objective: This study aimed to compare the serum levels of oxLDL-β2glycoprotein I in type 2 diabetes mellitus patients with eGFR values calculated using the CKD-EPI equation to assess the association with the pathogenesis of diabetic nephropathy. Materials and Methods: This study used a cross-sectional design carried out multicenter by purposive sampling in 2019 at Pasar Minggu Primary Health Center. Samples also obtained by previous researcher in 2015 at RSK. Dr. Sitanala and in 2016 at Pasar Minggu Primary Health Center. The Samples (n=180) were divided into two groups, which was eGFR ≥ 90 ml/minute/1.73 m2 (n = 118) patients and eGFR 60-89 ml/minute/1.73 m2 (n = 62) patients. Serum oxLDL-β2 glycoprotein I complexes concentration was measured by ELISA. Results: This study showed that there was no statistically significant differences (p = 0.262) in the comparison of serum oxLDL-β2glycoprotein I complexes levels in the eGFR ≥ 90 ml/minute/1.73 m2 group (0.51 ± 0.04 units/mL) and eGFR 60-89 ml/minute/1.73 m2 group (0.49 ± 0.05 units/mL). In addition, the mean comparison of serum oxLDL-β2 glycoprotein I complexes levels in the eGFR group ≥ 90 ml/minute/1.73 m2 and 60-89 mL/minute/1.73m2 with normoalbuminuria and albuminuria subjects also showed no significant difference (p = 0.071). Conclusion: There was no significant difference in serum oxLDL-β2 glycoprotein I complexes level with estimated glomerular filtration rate and the results of the analysis indicate that the serum oxLDL-β2 glycoprotein I complexes is not specific enough as a marker of early diabetic nephropathy.