Background: captopril has a hypoglycemic effect with the capacity to reduce blood glucose by increasing the rate of removal of glucose in the muscles. Objective: to determine the effects of Captopril on high-fat diet and low-dose streptozotocin diabetic rats. Materials and Methods: rats were divided into six groups (n = 7). One group untreated and five group (negative, positive, and three groups were variation doses of captopril) treated with high-fat diet and low-dose streptozotocin. Negative group was given 0.5% CMC, positive group was given Metformin dose 90 mg/200g /day orally, and three variation dose groups of captopril 25 mg/kg BW rats/day orally; 50 mg/kg BW rats/day orally; 100 mg/kg BW rats orally. Induced by high-fat diet (standard feed: quail egg yolk: butter: high fructose corn syrup, 5: 3: 1: 1) for 28 days, and then injection low-dose streptozotocin (30 mg/kg BW i.p) for 7 days, continued for 14 days treated with an oral administration. Results: all dose of captopril significantly reduced glucose level (p <0.05) but not dose dependent. The power of Captopril similar to metformin to reduce glucose level, captopril and metformin can reduce blood glucose levels back to normal. Conclusion: based on these results, Captopril has a potential effect as an anti-hyperglicemic agent.

Key words: Captopril. Glucose Level, High-Fat Diet, Low-Dose Streptozotocin, Off-Label