Bitter melon fruit are known to have substances that have antiinflammatory and analgesic activity, one of them is flavonoid. The aims of this research to determine the antiinflammatory and analgesic effects of bitter melon fruit (Momordica charantia L.) decoction. The antiinflammatory test method using the Winter method with 25 rats in the treatment group dose I (7 mg / 200 g BW), dose II (21 mg / 200 g BW), dose III (35 mg / 200 g BW), and diclofenac Sodium 8,2595 mg / 200g BW as a positive control. Analgesic test using the Siegmund method with 25 mice in the treatment group dose I (3 mg / 20 g BW), dose II (5 mg / 20 g BW), dose III (10 mg / 20 g BW), and diclofenac Sodium 1,1930 mg / 20g BW as a positive control. The results of the antiinflammatory percentage from bitter melon decoction dosages were 10.06%, 12.88% and 22.04%. The results of the analgesic percentage from bitter melon decoction were 36.05%, 38.95% and 50.31%. The conclusions of this research showed bitter melon fruit decoction has anti-inflammatory and analgesic activity.

Key word : Bitter melon fruit, decoction, anti-inflammatory and analgesic activity.