Background: Diabetes mellitus is a disease characterized by increased blood glucose levels (hyperglycemia). Diabetic wound healing is slower than the healthy individuals. Both sweet orange (Citrus sinensis) and pomegranate (Punica granatum) peel have an antihyperglycemic effect. Objective: This study investigated the effect of the combination of both these plants on blood glucose levels and wound healing in alloxan induced diabetes rats experimentally. Materials and Methods: Rats were divided into 4 groups. One group as a normal group and 3 treatment  groups that induced by intraperitoneal injection of a single dose of alloxan 200 mg/kg. One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided into diabetes groups that given CMC 1%, the group that given a combination of ethanol extract of sweet orange peel 100 mg/kg and ethanol extract of pomegranate peel 50 mg/kg and the group that given combination of ethanol extract of sweet orange peel 200 mg/kg and ethanol extract of pomegranate peel 100 mg/kg. The treatment was given for 12 days. Blood glucose levels and the rate of wound closure were measured on the twelfth day. Results: The combination of sweet orange and pomegranate peel extract showed significant (p ≤ 0.05) reduction in blood glucose and time to wound closure compared with the normal and diabetes control. Conclusion: Based on these results, a combination of sweet orange and pomegranate have a potential effect as an antidiabetic agent and treatment of chronic wounds in diabetes.