Background: Recently, a number of studies have investigated genetic polymorphisms as a possible factor contributing to the development of endometriosis. In this study, we try to determine the association between single nucleotide polymorphisms (SNP) and ovarian endometriosis in PGR gene.

Methods: This research is a case-control study comparing 30 women with ovarian endometriosis and 17 women without endometriosis. We used sequencing method to determined polymorphisms in PGR gene. Statistical analyses was Chi-square test, a two-tailed p value less than 0,05 was considered significant.

Result: We found that there was statistically significant difference of PGR genotypes rs1042838 between ovarian endometriosis and controls, p=0,015. We also found there was a new mutation in PGR gene, eventhough there was no statistically significant. There was association between the allele distribution rs1042838 in ovarian endometriosis and controls (p=0,012; OR=5,040), but not the new mutation (p>0,05; OR=0,694).

Conclusion: Our result further support the idea that the PGR gene polymorphisms may be associated with an increased risk of endometriosis.

Keywords: Polymorphisms, Progesterone receptor, endometriosis