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The objective of this study is to develop the mobile application of android-based interactive learning with 2D animation technique in SMK. The method is used the Research and Development (R&D) as well as models used in the development process of interactive learning media of 2D animation techniques using Multimedia Development Life Cycle (MDLC) model through 6 stages. Data sources are the quantitative data as basic data and qualitative data as additional data in the form of suggestions from respondents through a poll with the subjects are student of XI Multimedia class study at SMK Negeri 1 Sonder. The data analyzed using qualitative descriptive statistics. It’s found that the development of android-based 2D animation interactive mobile learning application through the concept stage, designing, material collection, manufacture, testing and distribution, and application feasibility to interactive mobile learning android-based 2D animation techniques is categorized a very good, and based on student/respondent trials is in good category with an average overall score of 3.62 with a percentage Media quality 75.2%. This 2-dimensional interactive learning media is worth using to support the teaching and learning activities of students of XI Multimedia class at SMK Negeri 1 Sonder.