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In recent years there has been a disease in rubber plants caused by the fungus Pestalotiopsis sp which causes massive rubber leaf falls. Pestalotiopsis sp grows and develops in areas with high and humid rainfall and humidity. The Sembawa Rubber Research Center garden is a garden for conducting research and developing rubber plants. This study aims to examine the phenomenon of leaf fall of rubber plants due to Pestalotiopsis sp spatially and temporally as well as the influence of rainfall and humidity factors in the garden area. Rubber leaf fall was calculated using the vegetation index and %treecover from Sentinel 2A and drone images. Rainfall and humidity were obtained through CHIRPS and SMAP images. The results showed a significant relationship between the NDVI value and the leaf fall rate of rubber plants. Rubber leaf fall rate due to Pestalotiopsis sp has a significant relationship with rainfall spatially and temporally. Meanwhile, the humidity did not significantly correlate with the incidence of rubber leaf falls. Natural leaf fall occurred in August 2020 marked by low rainfall and humidity levels. December 2020, March, May, and November 2021, leaves fall due to the attack of Pestalotiopsis sp which is characterized by high rainfall and humidity values.