Background. Cardiovascular disease is a health issues caused by heart problems, such as coronary heart disease, heart failure, hypertension, or stroke (Ministry of Health, 2014). Based on WHO data (2017), heart disease is the number one cause of death in the world. Every year, many people die from cardiovascular disease when compared to other causes. An estimated 17.7 million people die of cardiovascular disease in 2015, representing 31% of deaths worldwide. In heart disease patient, heart-related quality of life (HRQoL) is one of the important context of prevention and treatment in heart disease. HRQoL refers to the impact of health conditions and symptoms that individuals have on quality of life (Ski & Thompson, 2010). HRQOL also represents the patient's evaluation of the impact of the disease on their physical function and well-being (Sheperd & While, 2012). HRQoL indicates the patient's perception of general, physical and mental health status, and describes the health aspects of a population. HRQoL also evaluates how individual welfare over time can be affected by illness, disability, or a disorder (Centers for Disease Control and Prevention, 2000). One of the main goals of cardiovascular care is optimal HRQoL for patients (Schweikert, Hunger, Meisinger, Konig, Gapp, & Holle, 2009). Wang, Hay, Clarke, and Menahem (2014) revealed that for patients with chronic diseases, psychosocial factors such as understanding of disease, social support, and anxiety and depression are important things to note. More specifically, Moser (2007) suggests that anxiety is the most common thing that occurs in individuals with heart disease. The prevalence of anxiety disorders is substantially greater in the population of cardiovascular diseases than in the general population (Todaro, Shen, Raffa, Tilkeimeier, & Niaura, 2007). Anxiety has a high prevalence, which is around 70% to 80%, and can survive in the long term in 20% to 25% in individuals who have heart problems (Moser, 2007). Besides anxiety, HRQoL in heart disease patients also caused by other factors. Farcas and Nastasa (2011) stated that coping strategies in people with heart disease can affect their quality of life. Meanwhile, Stafford, Berk, and Jackson (2009), found that illness perception can affect HRQoL, for example, individuals who has positive mind about their disease can increase HRQoL. This shows a continuity between illness perception and coping strategies. It can be said that the illness perception possessed by individuals will influence the ability of coping strategies, where the ability of coping strategies will influence psychological aspects, one of which is the quality of life of individuals. Based on the explanation above, researchers formulated that individuals who suffer from heart disease are susceptible to anxiety, where the high level of anxiety will reduce the level of HRQoL they have. However, there is a possibility that individuals who have anxiety are also maintained by the HRQoL. This is presumably due to other factors, namely the ability of adaptive coping strategies in the individual, and also illness perception. This study aims to see anxiety, and also another factors that will or will not affect HRQoL

Methods. This study will consist approximately 100 adult participants, having a heart disease for more than 1 year. The data collection will use Patient Health Questionnaire 4 (PHQ-4) as the measurement for anxiety, and Short Form 12 version 2 (SF12v2) to measure HRQoL. To find another psychosocial factors in heart disease patients, Brief Cope (BC) and Brief Illness Perception will be use as well to measure coping strategies and illness perception, respectively.

Results. It is expected that anxiety will directly affect HRQoL. It is also expected that the relationship between anxiety and HRQoL affect by coping strategies, which related to illness perception.

Conclusions. Conclusions can be drawn upon the completion of the study.

Add-on Values. The results are expected to describe factors affecting HRQoL in heart disease patients. The findings are also expected become a basis on heart disease intervention targeting on HRQoL.

Keywords: Anxiety, Heart-related Quality of Life, Heart Disease, Psychology