Background: The life of women with HIV is never easy. Women with HIV, particularly housewife tend to have more stigmatized, more physical and psychological impact of HIV than men. Once the women disclosure their HIV status, they are at risk of living painful than men. As a consequence, stress and low quality of life among housewife with HIV. The aim of the study was to evaluated the relationship between HIV disclosure, stigma with quality of life among positive HIV housewives in Kupang.

Methods: A cross sectional study design was conducted in 2019 in Kupang, NTT. The participants were recruited at outpatient VCT clinic Sobat in Hospital in Kupang.

Results: A total of 120 HIV positive of housewives involved in this study. Most participants were married (66.7%), age group 18-40 years (78.3%), senior high school graduate (54.2%), More than half had high HIV disclosure (66.7%), had high stigma level (61%) and 75% had moderate stress level. Stress, and stigma were found significantly associated (P < 0.05) with quality of life. Moderate stress level of respondent was found the significant contributing factors in quality of life (p = 0.009; α = 0.005; OR = 7.667; 95% CI = 1.678-35.032).

Conclusion: Stress and stigma are associated with quality of life inhousewives with HIV in Kupang, but only the stress variables was found the significant factor. Reducing stigma should be the main focus in education and HIV prevention in order to improve quality of life HIV housewive in Kupang.