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Introduction: Xerosis is a skin complication of diabetes mellitus that often occurs. Giving moisturizers to the skin of patients with diabetes mellitus needs to be done to prevent further complications. There are no studies that examine the benefits of aloe vera on the xerosis skin hydration status of people with diabetes mellitus. Objective: This study aimed to determine the effect of moisturizers containing 5% aloe vera extract on the skin hydration status of xerosis patients with diabetes mellitus. Methods: This study was a double blinding randomized controlled trial (RCT) using time series design on 93 respondents with a sampling technique using consecutive sampling. Each respondent measured the hydration status of the stratum corneum before being given a moisturizing application and after being given the application. Posttest measurements were carried out 1 hour, 2 hours, 3 hours, and 7 days later. Data analysis using Wilcoxon signed rank test, independent t-test, and Anova. Results: There were significant differences between the values of the pretest and posttest hydration status in both the control and aloe vera groups. Moisturizers containing aloe vera extract 5% significantly improve skin hydration status better than controls. Observations on the difference in the value of hydration status between control group and aloe vera group showed that the mean difference of the aloe vera group was greater than control group. Conclusion: Moisturizers containing aloe vera extract 5% are effective for xerosis skin care for patients with diabetes mellitus and can be a therapeutic choice for treating skin disorders.