Hormonal and lifestyle changes during pregnancy, including physical inactivity and weight gain. These changes are beyond women’s control and are among the first changes making them mentally and spiritually vulnerable. The present study was conducted to investigate the quality of life in pregnant women, the assessment scales used to measure this variable and the factors associated with it. Mental and physical health of pregnant women. The present study searched databases including Science Direct, PubMed, Scopus, and Google Scholar using keywords such as pregnant women, quality of life, and pregnancy to find relevant articles review without any regard for their language and publication site. Result: the instruments have used to assess quality of life in pregnant women in these studies including SF-12, SF-36, QOL-Grav, and WHOQOL-BREF. The mean quality of life score obtained using these different tools varied from 2.9±0.3  to 91.05 ±10.04. Social support, socioeconomic status, the pregnancy being wanted, satisfaction with life and sexual function were related directly to the quality of life, while prenatal mental disorders, the severity of pregnancy nausea and vomiting and sleep disorders were related inversely to it. Factors are directly and significantly related to the quality of life during pregnancy, including depressive symptoms, gestational age, place of receiving prenatal care, cultural difference, restriction on diet and daily activities, age, satisfaction with the economic situation, satisfaction  with the cooperation  and participation of spouse in household chores, sleep disorder, pre pregnant weight