The increasing incidence of cervical cancer in the world needs to be taken into account by all governments. Screening test can provide earlier indication of the possibility of women having cervical cancer. The low awareness of cervical screening among women and their families is do to lack of their knowledge, attitudes, and self-efficacy. This research was conducted to identify the effectiveness of FEMALE health education on the knowledge, attitudes, and self-efficacy of women in the Banjarbaru Selatan District, Banjarbaru. The quasi-experimental pre-post test with control group design was used. The sampling technique uses convenience sampling. Data was collected from 428 housewives, with 213 in the control and 215 in the intervention groups respectively. The results showed that there was a significant differences before and after intervention in knowledge, attitudes, and self-efficacy in women (p = 0.000, p=0.003, and p=0.002 respectively) in the intervention group which is also different from respondent’s knowledge, attitudes, and  self-efficacy in the control group. This study recommends that nurses could use this FEMALE health education to educate women in the community in order to improve the coverage of cervical cancer screening.