Introduction: Gratitude interventions effect on various mental health indicators. However, limited reviews discus this outcomes systematically, thus systematic review identifies the effects of gratitude on mental health variables.

Methods: This systematic review used articles obtained from ScienceDirect and PubMed by applying keywords of gratitude intervention and mental health, published in 2015-2019, full-text, in English, and using a randomized controlled trial (RCT) design. Articles are selected through the process of determining research questions, literature search, reference analysis, and formulating results.

Results: There were 6 eligible articles with further analysis revealed that gratitude influences decreasing negative emotions (stress and depression) and increasing positive emotions (life satisfaction, social relations, and create a positive environment).

Conclusion: Gratitude has a positive influence on mental health conditions, so that this intervention can be integrated into the nursing process.