Background:To study the effect of omega-3 rich fish oil on the histopathology of kidney in mice induced by azoxymethane and DSS.

Method: The experimental mice that had been induced using AOM 10 mg/kg and DSS 2% for 2 weeks were allocated randomly into 4 groups as follows; Control Group: mice recieved no fish oil, Low Dose Group: mice recieved 1.5 mg/day fish oil, Medium Dose Group: mice recieved 3 mg/day fish oil, High Dose Group: mice recieved 6 mg/day fish oil. The omega-3 rich fish oil were given for 12 weeks.

Result: The administration of high dose omega-3 rich fish oil was able to reduce the amount of necrosis foci and inflammation foci compared to the control group (p<0.05). Moreover, the administration of low, medium, and high dose omega-3 rich fish oil were able to reduce the amount of vascular edema and cell degeneration foci (p<0.05). The administration of medium and high dose omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p<0.05) compared to the control group.

Conclusion: The result suggest anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.