Introduction: The implementation and documentation of discharge planning at Fatmawati Hospital was not optimal. This study aims to identify the relationship of self-directed learning readiness and the nurse’s knowledge about discharge planning at Fatmawati Hospital, Jakarta. Method: The study design used descriptive correlation with the approach of cross sectional in 110 nurses selected with simple random sampling . The measuring instrument uses the Self-directed Learning Readiness Scale (SDLRS) to measure the readiness for SDL implementation, and the Nurse Knowledge about Discharge Planning Questionnaire. Results : The results of the statistical test stated that the self directed learning readiness and nurse’s knowledge about discharge planning had a significant relationship (p value 0.005). Implementing nurses who have low self-directed learning readiness have the opportunity to have good knowledge about discharge planning 6 times compared to nurses who have high SDLR (95% CI OR 1,780; 19,275). The magnitude of the determinant coefficient is known that the SDLR has an effect of 13.3% on the nurse’s knowledge about discharge planning, and the rest is influenced by other factors. Conclusion: External factors influence the self-directed learning readiness so that it can increase the nurse’s knowledge of discharge planning.  Nursing managers need to believe in a nurse as a long-life learner, improve the role and function of management, and create a conducive environment, culture and climate of the organization to conduct independent learning in the workplace.