Depression is a common mental disorder in the older people. The rate of depression increases when the older people live in social institutions. Spiritual aspects can be used for depression care in the older people. Reminiscence therapy is a psychosocial intervention that is often used for the older people. This study aimed to know the effect of the spiritual reminiscence group therapy on depression in the older people at the social institution. This research used quasi experimental pre-posttest with control group design with the sampling technique used was purposive sampling. This research was conducted at the Social Institutions in South and Central Borneo using a Short Form Geriatric Depression Scale (GDS). The intervention was conducted in 12 sessions for 6 weeks. The sample amounted to 67 people (mean age = 68,22 years) in the intervention group and 64 people (mean age = 71,52 years) in the non-intervention group. The results of the mean difference analysis in depression before and after the intervention between the intervention and non-intervention groups showed p value = <0.001; α = 0.05. Spiritual reminiscence group therapy has been shown to reduce depression in the older people at the social institution. The Social Service is expected to provide varied activities such as recreational activities alongside religious activities.