Objective: The complexity of care on patient with gynecological and breast cancer causes various psychological effects and therefore, spiritual-based intervention is developed to overcome these problems. The purpose of this study is to determine the effect of spiritual-based intervention on psychological aspect of patient with gynecological and breast cancer.

Methods: The method used to preparethis systematic review is Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA).

Results: There are 14 related articles. The effect of spiritual-based intervention on psychological aspect of cancer patient includes reducing anxiety and depression, improving spiritual and emotional well-being, and improving coping and quality of life for patient with gynecological and breast cancer.

Conclusions: Spiritual based intervention has varying effects, for example, affecting the physical condition, psychological state, and quality of life of cancer patient. This intervention can be developed more to enhance nursing care practices.Nursing implication and recommendation are relate to further research on the effectiveness of this intervention for cancer patient in Indonesia. It is expected that spiritual-based intervention should be used as part of holistic nursing care for cancer patient.