Treatment for nasopharyngeal cancer has been proven to enhance patients’ prognosis of cancer. However, it is undeniable that nasopharyngeal cancer patients also chronically suffer from the side effects in the form of head and neck dysfunctions. Self-management is one of the promising strategies in managing a chronic condition, but it is complex and individualized. Therefore, this review was carried out to understand the self-management experience among the patients throughout their cancer trajectory. Five databases were systematically searched from February to April 2018. The studies were thematically analyzed. Several important themes emerged in term of their needs, facilitators, barriers, strategies, and provision of support towards self-management. Need for sufficient and appropriate information was the highest concern among nasopharyngeal cancer patients. Understanding self-management from the patients’ perspectives may draw attention to specific concerns for self-management. However, the study of nasopharyngeal cancer patients is still under-researched. Exploratory research to understand their unique self-management experiences may help to design the care and support tailored to them in order to provide more holistic yet individualized care.