The Cisadane River that crosses the Tangerang area every year enters 14-17 tons of garbage entering from the surrounding land and along with the flow of water from its upstream. The influx of large amounts of garbage makes the function of the river as a source of raw water and flood control becomes disrupted. This research was conducted with the aim to determine the impact of waste pollution on the Cisadane River in Tangerang Region. In addition, this study can conclude that waste has caused: siltation in several parts of the river such as riverbanks. The volume of waste from 13 subdistricts in the Tangerang area, in August 2018 which is usually 14 tons to 17 tons, is compounded by the presence of garbage carried from the water flows of Bogor Regency and South Tangerang .  Whereas 61% of the area is residential, 18% are paddy fields and 17% are airports; so that it can be understood if floods always occur in some areas of Tangerang City. This study concluded that waste has caused siltation at the edges, bodies and banks and disrupted the function of the Cisadane River.  In addition, certain areas are susceptible to flooding such as Karawaci District, Priuk District and Neglasari sub-district, Curug District, Kosambi District, Mekar Kondang District, Paku Haji District, Sindang Jaya District, Teluk Naga district.