The Pesanggrahan River from the characteristics its river width is an intermediate river. The chemical and biological content of Pesanggrahan River water shows that the Pesanggrahan River has been polluted. Water pollution in the Pesanggrahan River is greater in the downstream area, this is due to the accumulation of chemical compounds from industrial and domestic waste. Most of the Pesanggrahan Watershed are residential areas. City development in the Pesanggrahan Watershed has a major influence on the decline in the water quality of the Pesanggrahan River. The biggest development occurred in the period 2004-2010. Then, in the 2010-2013 period the development was more on the changes in the structure of the Pesanggrahan River flow, namely on river widening and straightening. The area in the Pesanggrahan Watershed is widely used as an illegal industrial area, thus violating existing spatial provisions. The role of the Jakarta City Government in maintaining river water quality is in the function of building and supervising buildings that violate the rules. This refers to the granting of permits and finally to prosecution of parties who violate and play a role in decreasing the quality of the Pesanggrahan River water.