Kidney disease is a common disease worldwide. The leaves from Pterocarpus indicus Willd. is alternatively applied for prevention therapy of patients with kidney diseases. The aim of this study was to demonstrate the scientific nephroprotective effect of water-boiled P.indicus leaves evaluated from urine volume, sodium and potassium levels. Thirty male Sprague-Dawley rats were divided into five treatment groups; group I (control), group II (gentamicin-induced 80 mg/kg i.p from day 15to 21), and group III to V (induced; variated doses respectively 28.8 mg/kg; 57,6 mg/kg; and 115,2 mg/kg body weight which were given orally for 21 days as single doses). Nephroprotective effects were observed as abnormal from levels of urinary volume. Obtained results on sodium and potassium levels show the group given the highest dose (115,2 mg/kg) resulted in decreased sodium levels and increased levels of urinary potassium as well as having a significant difference (p<0,05) to the induction group. Observed 24-hour urine volume, however, did not show any significant signs for nephroprotective effects. It can be concluded that the leaves of P.indicus has potential nephroprotective properties.