Universitas Indonesia Conferences, 1st International Conference on Advance Pharmacy and Pharmaceutical Sciences

Font Size: 
Safety and Activity Test of Hair Growth Ethyl Acetate Fraction of the Scutellarium Leaves (Nothopanax scutellarium Merr.) in Hair Tonic Formulation
Via Rifkia

Last modified: 2016-11-02


Based on the traditional use and previous researches, nothopanax scutellarium leaves had been known can to enhance hair growth. Nothopanax scutellarium leaves hair growth activity influenced by flavonoid compounds. The aims of this research were to know the ethyl acetate fraction safety by looking at the nature of irritation toward chorioallantoic membrane and to know the fraction of test effectivity of scutellarium leaves toward hair growth activity in hair tonic formulation by 0.25%; 0.5%; and 1% fraction concentration. Safety test measured by scoring and cathegorizing irritation within chorioallantois membrane. Hair growth activity test had been done by dropping and rubbing hair tonic formulation on the back of the rabbits which classified to 6 areas testing and the length of hair is measured in 1st, 2nd and 3th week. In the 3th week, the weight of rabbits hair growth in the areas testing is weighed and hair diameter also measured by SEM (Scanning Electrone Microscope) method. The result of safety test showed that 0.2 gram of ethyl acetate fraction of nothopanax scutellarium leaves have mild irritation effect. The result of hair growth activity test showed that the 0.5% and 1% concentration of formulation had more faster hair growth and also enlarging hair diameter.
Keywords : nothopanax scutellarium leaves; safety test; hair tonic; hair growth activity.