Diabetic nephropathy can be detected by UACR value and eGFR. Meanwhile, 8-iso-Prostaglandin F_2α is being studiedfor its role as early marker for renal dysfunction.  This study were to analize 8-iso-Prostaglandin F_2α, UACR, and the correlation between 8-iso-Prostaglandin F_2α and UACR on 72 type 2 diabetes mellitus patient (from ages: 33-75 years) at Pasar Minggu Community Health Center. Samples were divided into two groups, which was  biguanid group (n = 36) and biguanid-sulfonylurea group (n = 36). Urinary 8-iso-Prostaglandin F_2α was measured by ELISA and urinary albumin was measured by BCG Albumin kit. The results of mean different test showed there were no difference for 8-iso-Prostaglandin F_2α (p=0,083) and UACR (p=0,509) in two group samples. The results of mean different test showed there were also no difference for 8-iso-Prostaglandin F_2α (p=0,532) and UACR (p=0,067) in group samples with albuminuria (n=33). The correlation between 8-iso-Prostaglandin F_2α and UACR on total samples (r = 0,120; p = 0,315), meanwhile the correlation between 8-iso-Prostaglandin F_2α with UACR on samples with albuminuria (r = 0,534; p = 0,001).  So, there was no significant correlation between 8-iso-Prostaglandin F_2α and UACR on total samples, meanwhile there was strong enough and significant correlation between 8-iso-Prostaglandin F_2α and UACR on samples with albuminuria.