Melinjo Seeds (Gnetum gnemon L.) contains many stilbene derivative and phenolic compounds which known efficacious as antihypertensive by inhibit the Angiotensin Converting Enzyme (ACE). The purpose of this study was to analyze the inhibition of ACE activity and total phenol content, also to analyze the correlation between the two. In this study, Melinjo seed was consecutively extracted with reflux method using five different solvents such as n-hexane, dichloromethane, ethyl acetate, methanol, and water. ACE inhibitory activity was tested using ACE-kit-WST and the highest ACE inhibitory extract tested with IC₅₀ while determination of total phenolic content was measured by Folin-Ciocalteu method. The results of ACE inhibitory activity showed that the ethyl acetate extract is an extract with highest ACE inhibitory activity 92.11%, then the methanol extract 90.64%, dichloromethane extract 89.93%, water extract 89,81%, and the lowest is n-hexane extract 79.29%. Furthermore, IC₅₀ results show the ethyl acetate extract is 9,77x10^-8 µg/mL and IC₅₀ value captopril is 1,13x10^-12 µg/mL. The results of determination of total phenolic content showed that ethyl acetate extract is an extract with the highest phenolic content 575.884 mgGAE/g, then the methanol extract 398.551 mgGAE/g, dichloromethane extract 104.102 mgGAE/g, water extract 41.224 mgGAE/g and the lowest is n-hexane extract of 30.611 mgGAE/g.