Universitas Indonesia Conferences, 1st International Conference on Advance Pharmacy and Pharmaceutical Sciences

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Formulation of Niosomal Gel with Green Tea Extract (Camellia sinensis L. Kuntze) using Thin Layer Method
Astrid Permatasari Isnan

Last modified: 2016-11-11


Green tea has been known as a source of antioxidant. (-)-epigallocatechin gallate (EGCG), which is the most abundant antioxidant contained in green tea, has been shown to modulate biochemical pathways of skin. Niosom is an alternative to liposome drug vehicle systems which has disadvantages including cost and stability. Niosome was prepared for enhance stability of drug. Niosomal formulations were prepared in four different molar ratios of surfactant-cholesterol, i.e. 3:1 (F1), 2:1 (F2), 1:1 (F3), and 0.5:1 (F4). Niosomal formulations were prepared using thin layer method. Niosomal suspensions were evaluated including particle size and distribution, lamellarity, encapsulation efficiency, and zeta potential. Niosomal suspension, which had been evaluated, then incorporated into gel using HPMC as gelling agent. Niosomal gel was evaluated including organoleptic, pH, viscosity, stability, and antioxidant activity using DPPH. Evaluation of niosomal suspensions showed that F1 has best encapsulation efficiency but experienced separation after 7 days. Evaluation of niosomal gel (using F3) showed stable formulation without changes.