ABSTRACT

Angsana leaves (Pterocarpus indicus Willd.) has been widely used empirically for treat canker sore, antibacterial and kidney disease. This study aimed to demonstrate the scientific of nephroprotective effect from water stew of  angsana leaves on male rats induced by gentamicin reviewed from urea and creatinine plasma levels were both parameters of renal function. In this study, thirty (30) male rats strain Sprague Dawley were divided into five treatment groups. The treatment groups consisted  of normal control group was given aquadest orally and aqua pro injection, induction group was given gentamicin intraperitonial injection with dose 80 mg/kg bw/day, dose I group was given water stew of angsana leaf with dose 28.8 mg/kg bw/day, dose II group was given water stew of angsana leaf with dose 57.6 mg/kg bw/day, dose III group was given water stew of angsana leaf with dose 115.2 mg/kg bw/day. All groups were given treatment  for 21 days. At the 15^th day, the animals were given gentamicin intraperitonial injection for 7 days. At the 22^th day, the blood was collected from sinus orbital. The urea and creatinine plasma levels were measured by berthelot method for urea and colorimetric method for creatinine. The result show dose III group was decreased urea and creatinine plasma levels also has significantly different (p<0,05) with induction group. So, dose III group was given water stew of angsana leaf  with dose 115.2 mg/kg bw/day has potential to prevent kidney damage induced by gentamicin.