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Guillain-Barre syndrome (GBS) is a rare condition in which the body’s immune system attacks peripheral nervous system, it is leading to muscle weakness and even paralysis that will associated with loss of independent living status. The aim of this study was to examine the effects of functional mobility training on performance of Activities Daily Living (ADL) and Proprioceptive Neuromuscular Facilitation (PNF) pattern in the water on the muscle strength in Guillain Barre Syndrome (GBS) patient. In this study, the patient have performed functional mobility training and PNF pattern in the water for 4 weeks. Manual Muscle Testing (MMT), and Barthel Index measurements were evaluated before and after the intervention (once in a week). After 4 weeks of functional mobility training and PNF pattern in the water, Barthel Index score and MMT of all extremities showed statistically significant difference, there were greater improvements in the scores of Barthel Index and MMT. In this study showed that, functional mobility training and PNF pattern in the water had significant effects on the muscle strength and performance of Activities Daily Living in Guillain Barre Syndrome (GBS) patient.