The research aims to examine the effect of capital expenditure (CAPEX) and market share against profits per Region in PT. Telekomunikasi Selular (Telkomsel). This research uses all Regions (10 Regions) during the year 2009-2016 (8 years), resulting to 80 observations. This research uses panel data regression model. This research shows that CAPEX does not have influence on profit, while the market share has an influence on profit. Although CAPEX has no influence on profit, the company should continue to spend capital expenditure for investment to meet customer needs, especially the mobile telecommunications industry belonging to the industry with rapidly obsolete technology therefore companies should be more selective in making investments. Performance period used in this research may cause CAPEX does not have influence on profit, CAPEX in prior year not reflect profit in period performance. Market share has an influence on profit, with a large market share, the company has strengths include: economies of scale, market power and quality management.