This research examine about the effect of the Technology Infrastructure in CRM on the Profit Increases with CRM Process mediating. Research conducted on conventional banks listed on the Otoritas Jasa Keuangan that has its Head Office located on DKI Jakarta excluding foreign banks and Islamic banks. The study sample consisted of 30 banks which is willing to return the research questionnaire. In testing hypothesis on path analysis, data was processed by using LISREL 9 and reliable by testing its validity and reliability using SPSS v.22. The results found if the Technology Infrastructure in CRM significantly affect CRM Process, but there is no effect at the Technology Infrastructure in CRM on the Profit Increases. On the other hand, CRM Process can increase the profit significantly, so that CRM Process can mediate the effect of Technology Infrastructure in CRM on the Profit Increase. Research shows indicators of the CRM Process and Technology Infrastructure in CRM relatively high but the profit growth was not determined by the Technology Infrastructure in CRM directly, that CRM Process should be mediating the effect to some banks that becomes sample to this research.