This study addressed an important issue about infant mortality in Indonesia. This paper aimed to investigate the impact of maternal smoking on infant mortality in Indonesia that was controlled by other maternal factors and socioeconomic variables. Using survival analysis, the results showed that maternal smoking significantly affects infant mortality (p < 0.05). Including control variables, the infant who exposed to maternal smoking has increased the risk of infant mortality by 62,8 percent higher (Hazard Ratio = 1,628) than the infant who unexposed. This study supports health policy initiatives to reduce the number of the smoking person and regulate other policies that related to tobacco.