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Background: Clindamycin, an antibiotic compound, is a prosperous product for microbial infections treatment. Clindamycin is a semi synthetic derivative of lincomycin, a natural antibiotic produced by the actinobacterium Streptomyces lincolnensis which was isolated from soil, a natural reservoir of actinomycetes. The work that focuses on screening and isolation of indigenous microbes was conducted by another research group. Implementation of antibiotic research group has focus on its application such as topical application of clindamycin phosphate to treat mild to moderate acne. In addition, the effectiveness of clindamycin was also influenced by the sensitivity of skin and how severe level of the infection. In case of topical preparations for skin, clindamycin was prepared in gel that gives many advantages over other topical dosage forms; easier in usage on the skin and cleaning. Based on previous experience, to improve therapeutic effectiveness and comfort in its use, the clindamycin gel preparation is made on a carbomer base. Objective: This study aimed to observe and to figure out the best carbomer clindamycin gel formulation. The influence of clindamycin for acne treatment was observed due to its inhibitions to protein synthesis in sensitive and bacteriostatic. Materials and Methods: The suspensions made of small inorganic particles or large organic molecules and penetrated by a liquid. The carbomers often used in gel preparation were marked as carbomer 934 and carbomer 940 whereas the difference lies in the viscosity. The gel preparations were evaluated on how effective the treatment was. Various concentration of gel was examined for the infection. The observation for evaluation was carried out at physical and chemical tests. Physical test comprised of organoleptic test, homogeneity, spread-ability, viscosity, adhesion and hedonic test while chemical tests were conducted by observation for the pH and assay. Results: The evaluation was conducted for 2 formulas. The first gel formulation, carbomer 934, with pH of 5.69, viscosity of 8900 cPs, spread of 19.6 cm², adhesion for 1 second, gave level of 109.03%. Another evaluation formula 2, carbopol 940, with pH 5.82, viscosity 45000 cPs, spread of 16.6 cm², adhesion for 0.45 seconds, gave content of level 96.27%. Conclusion: The hedonic test concluded that the panellists for how ease of application, softness, sensation and cleaning, the formula 1 was preferred rather than formula 2. In addition, this quality of gel formulation 1 was also comparable with the market leader products.