Background: Diabetes is a syndrome that is caused by a relative or an absolute lack of insulin. Impaired insulin secretion and resistance to the action of insulin, rather than an absolute insulin deficiency, characterize patient with type 2 diabetes. Diabetic nephropathy is a leading cause of end stage renal disease. Drug utilization studies could promote rational drug use. Objective: The project aimed to assess and evaluate the rationality of drug use in patients with type 2 Diabetes Mellitus complication of Diabetic Nephrophaty inpatient care at dr. M.Djamil Hospital Centre Padang. Materials and Methods: A prospective, crossectional method was conducted in this non experimental research. The demographic, disease and treatment data of patients with diabetic nephropathy were collected for a period of three months and analysed. The appropriateness of antidiabetic usage based on criterion Ministry oh Health, such as the appropriateness of indication, the appropriateness of patient, the appropriateness of regiment, the appropriateness of drug and caution of side effect. Results: The results showed that antidiabetic and antihypertensive usage on that hospital were 100% appropriate in term of indication, patient, drug and caution of side effect. While evaluation to appropriateness of antidiabetic and antihypertensive drug regiment  were 57% and 90% respectively. Conclusion: This study find anappropriate in drug regiment.

Key words: Diabetes Mellitus, Type 2, Diabetic nephropathy, rational drug use