Peperomia pellucida (L.) Kunth. is a herb which traditionally used to treating many diseases such as abdominal pain, gout, renal disorder, and rheumatic joint paint. Recent study published that in- vitro study of Peperomia pellucida has potential as antidengue treatment. Besides toxicology researched showed that Peperomia pellucida was slightly toxic, and as an drug-antidengue potential ahead for pregnant women which also suffered dengue, it is necessary to do an advance research on teratogenic effects of Peperomia pellucida plant ethanolic extract on the morphology of mice strain DDY. As many as 25 pregnant mice (DDY, 2 months age) used, based on randomized completed design 5 treatment and 5 replicated. Ethanolic extract of Peperomia pellucida were administrated orally at dosage: 0,5 (KP1); 5 (KP2); 50 (KP3); and 500 (KP4) mg/kgbw in 6 to 15 days of gestation. The remaining animals were used as an untreated (KK/control) were given by aquades in 6 to 15 days of gestation. Twenty five pregnant mice were sacrificed and cesarian sectioned at 18 day of gestation to remove the fetuses and then check fetus body weight and height, life fetus, death fetus and morphology of fetus. The data were analyzed parametically with one way Anova test (α=0,05) and nonparametically with Kruskal-Wallis test (α=0,05). The research showed that the administration of Peperomia pellucida ethanolic extract, orally from 6 to 15 days of mice gestation, started from dose 50 mg/kgbw may cause morphology defect. The morphology defect which found were hemorrage, dwarf, and open eyelids fetuses. However, the statistical analyses (P>0,05), based on Kruskal-Wallis test, showed that there were not significance difference to all groups. Peperomia pellucida ethanolic extract also did not affect the litter of fetus, weight and height of the fetuses.

Keywords: mice, morphology, Peperomia pellucida, teratogenic

Peperomia pellucida (L.) Kunth. is a herb which traditionally used to treating many diseases such as abdominal pain, gout, renal disorder, and rheumatic joint paint. Recent study published that in- vitro study of Peperomia pellucida has potential as antidengue treatment. Besides toxicology researched showed that Peperomia pellucida was slightly toxic, and as an drug-antidengue potential ahead for pregnant women which also suffered dengue, it is necessary to do an advance research on teratogenic effects of Peperomia pellucida plant ethanolic extract on the morphology of mice strain DDY. As many as 25 pregnant mice (DDY, 2 months age) used, based on randomized completed design 5 treatment and 5 replicated. Ethanolic extract of Peperomia pellucida were administrated orally at dosage: 0,5 (KP1); 5 (KP2); 50 (KP3); and 500 (KP4) mg/kgbw in 6 to 15 days of gestation. The remaining animals were used as an untreated (KK/control) were given by aquades in 6 to 15 days of gestation. Twenty five pregnant mice were sacrificed and cesarian sectioned at 18 day of gestation to remove the fetuses and then check fetus body weight and height, life fetus, death fetus and morphology of fetus. The data were analyzed parametically with one way Anova test (α=0,05) and nonparametically with Kruskal-Wallis test (α=0,05). The research showed that the administration of Peperomia pellucida ethanolic extract, orally from 6 to 15 days of mice gestation, started from dose 50 mg/kgbw may cause morphology defect. The morphology defect which found were hemorrage, dwarf, and open eyelids fetuses. However, the statistical analyses (P>0,05), based on Kruskal-Wallis test, showed that there were not significance difference to all groups. Peperomia pellucida ethanolic extract also did not affect the litter of fetus, weight and height of the fetuses.

Keywords: mice, morphology, Peperomia pellucida, teratogenic