Anthocyanin is one of kind flavonoid compound that is responsible for the pharmacological activity of a plant. One of the plants containing anthocyanins is red sweet potato leaves (Ipomoea batatas (L.) Lam. Var. Beta 2). Sweet potato leaves have potency hypoglicemia blood effect in vivo.

Objective: This study aimed to determine the hypoglycemia effect of red sweet potato leaves extract (RSLE) on Wistar male rats induced by STZ (streptozotocin).

Materials and Methods: RSLE was obtained by extracted the leaves using ethanol 95%, citric acid 3%. Rats were grouped into normal control, hyperglycemia control, glibenclamid 0.45 mg/kg BW, RSLE 0.055, 0.0825, and 0.11 mg anthocyanin/250 g of rat. In addition to normal control, all rats were induced hyperglycemia by STZ 40 mg/kg BW. Glucose blood level of rats increases at 72 hours. Rats were given treatment (glibenclamid and RSLE, in each group) for 21 days. Glucose blood level of rats was measured  on the 0th, 7th and 14th days of treatment. The difference in blood glucose levels between groups was analyzed by SPSS statistics.

Results: STZ can increase glucose blood levels 3 times the normal control because STZ is an diabetogenic agent that can damage the pancreatic beta cells. RSLE 0.055, 0.0825, and 0.11 mg anthocyanin / 250 g of rat was able to reduce blood glucose levels by 22.13%, 46.83% and 57.36% after 14 days of administration. RSLE dosing increases and the duration of administration is longer, it will cause the effect of hypoglycemia to be stronger.