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Gallic acid is a naturally polyphenolic acid which shows cytotoxicity against several cancer cells, as well as it displays chemo-preventive activity which is attributed to its strong apoptosis- inducing and antioxidant effects. Thus, gallic acid has become an attractive substance to be further developed due to its strong cytotoxic activity. In this study, we synthesized alginate-chitosan nanoparticle coated with gallic acid using ionic gelation method. The yield, size and morphology of the nanoparticles were determined by UV-Vis Spectroscopy, Transmission electron microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. Compared to free gallic acid, gallic acid-coated alginate-chitosan nanoparticles demonstrated higher cytotoxicity against breast t47D cancer cells. This cytotoxicity study suggesting gallic acid-alginate-chitosan nanoparticle could be a new potential candidate for the treatment of breast cancer.