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Coriander (Coriandrum sativum L.) is a plant that contains antioxidant compounds such as flavonoids. This study was conducted to determine the antioxidant effect of coriander leaves ethanol extract in male rats Sprague dawley given t-BHP to cause oxidative stress. The coriander leaves was collected from Depok, West Java. The extract was prepared by maceration of the leaves powder with 96% ethanol. The antioxidant activity test of the extract was carried out by measuring the concentration of malondialdehyde (MDA), activity of superoxide dismutase (SOD) enzyme and catalase enzyme of male rat blood and liver. The rats were divided into six groups: normal group, negative control group, positive control group, and three groups given the extract with a dose of 20 mg / day, 30 mg / day, and 40 mg / day orally. The results showed that the ethanol extract of coriander leaves could reduce MDA levels, increase the activity of SOD and catalase enzymes in blood respectively 21%, 58.7% and 13.6% while in the liver 18.6%, 6.7% and 44.0%. Based on the results, the ethanol extract of coriander leaves has antioxidant effect in the male rats with oxidative stress.

Key words: Antioxidant, coriander, Coriandrum sativum, oxidative stress.