Universitas Indonesia Conferences, Asian Federation for Pharmaceutical Sciences (AFPS) 2019

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Physicochemical Properties of the Nanoparticle Synthetic Glioma Inhibitor MMEO (3’-Metoksi-3”,4”-(Metilendioksi)- 2,5-Epoksilignan-4’-Ol-6-On)
Yusnita Rifai, Sartini Djide, Nurhaidah Eda

Last modified: 2019-07-12


MMEO (3'-Methoxy-3",4"-(Methylenedioxy)-2,5-Epoxylignan-4'-Ol-6-On) is a synthetic compound derived from DMEO compounds (3',6-Dimethoxy-3",4"-(Methylenedioxy)-2,5- Epoxylignan-4'-Ol). MMEO is indicated as one of the new anticancer candidates that has a strong affinity for glioma receptors. This compound is hydrophobic so it is difficult to dissolve in water and causes a decrease in bioavailability. The aim of this study is to determine the characteristics of physicochemical properties of formulated MMEO nanoparticles. Nanoparticles were prepared by precipitation-ultrasonication using DMSO (dimethyl sulfoxide) as a solvent and water as an antisolvent respectively, then they were stabilized with polyvinyl alcohol (PVA) as a steric stabilizer. The formed nanoparticles are characterized by several methods including XRD (X-Ray Diffraction), SEM (Scanning Electron Microscopy), and FTIR (Fourier Transform Infra-Red). The results of FTIR characterization showed no interaction between MMEO and PVA. Characterization by XRD method showed a reduction in the number of crystalline particles from pure MMEO compounds to MMEO nanoparticle. An average crystal size at a concentration of 25 mg/ml is 58,14 nm and at a concentration of 50 mg/ml is 7,30 nm respectively. The SEM result exhibited the morphology of MMEO nanoparticles such as thin, layered and irregular sheets with particle size at a concentration of 25 mg/ml (852,26 nm) and concentration of 50 mg/ml sequentially (178,65 nm).