Background: One of the allegations of increasing DFIs patients who are not handled properly is inadequate debridement and empiric antibiotic administration. Objective: This study aimed to compare the quantity of debridement and rationality of empiric antibiotics therapy against clinical outcome of DFIs patients. Materials and Methods: The study was conducted retrospectively during the period January-December 2017. The research data were collected using medical record patients who were diagnosed with DFIs who met the inclusion and exclusion criteria (aged >18 yrs). The rationality of antibiotics was analyzed using Gyssen algorithm. The relationship between quantity of debridement and empirical antibiotic rationality with clinical outcomes was analyzed using Chi square method. Results: The more frequent debridement will affect the clinical outcome of patients (P=0.002). However, antibiotic rationality did not show a linear relationship with the clinical outcome of patients (P=0.3815). Conclusion: Based on these results, antibiotic therapy have not been optimal due to the presence of co morbidities in DFIs patients.