Background: Hypertension is called the “sillent killer” where the sufferer does not experience symptoms before. The prevalence of hypertension in Indonesia is 26,5% with the population of West Java ranked 4th most. Seeing hypertension patients is quite high and there is a close relationship between hypertension and hyperlipidemia where both diseases are treated, it is necessary to identify Drug-Related Problems (DRPs) to avoid problems that occur in treatment, requiring appropriate treatment to avoid failure.

Objective: Identifying DRPs that occurs with the category of drug interactions, improper drug selection, subdosage, and overdosage.

Method: This study was conducted in a descriptive with a cross sectional approach at one of Puskesmas in Bandung in March – May 2019. The population study was data in the periode March-December 2018 wich was in accordance with the inclusion criteria. Sampling method was total sampling. Data was obtained from patient medical record.

Result: Sampels was obtained 64 patients. The highest number of hypertension patient with hyperlipidemia at one of Puskesmas in Bandung was female (67,3%), the highest rank was in age range 61-70 years old (40,6%). Hypertension with hyperlipidemia patients were still exprienced DPRs. Through identification of DRPs, 44 of 64 patients experienced potential drug interactions (amlodipine-simvastatin, amlodipine-mefenamic acid, amlodipine-diclofenac sodium, amlodipine-antacid), 7 of 64 patients experienced improper drug selection (potential contraindications), and 1 in 64 patients get overdosage.

Conclusion: Of four category of DRPs examined, the problems that occur include drug interactions (68,7%), improper drug selection (10.9%), and overdosage (1,56%). So that the role of phamacists is needed to provide information and education in order to minimize problems which occured in treatment.

Key Words: Drug-Related Problems, Antihipertension, Hyperlipidemia, Puskesmas