Backround: Over expressing of epidermal growth factor receptor (EGFR) in specific organ implicates a tumor aggression and proliferation. Therefore, EGFR becomes a basic consideration for targeted cancer therapy. Nanoparticle drug delivery system is a promising multifunctional techniques to provide the targeted drug delivery system. Objective Study: This review aimed to discuss about the nanoparticles formulation for targeted drug delivery in specifics EGFR. Methods: The data were collected from published journals recorded in the scopus data base since 2010 to present. Result: A various types of nanoparticles have been studied to provide EGFR-targeted drug delivery system in several cancer cells such as lung cancer, breast cancer, colorectal cancer, cellosaurus cell line (GLC-82), oesophageal cancer, glioma, glioblastoma, malignant pleural mesothelioma, pancreatic cancer, and other EGFR-positive cancer cells. Impressive results were shown from Superparamagnetic iron oxide nanoparticles with EGF conjugates, it can mediate targeted delivery across the blood-brain barrier and tumor retention of the nanoparticles, and the accumulation revealed as hypotensive zones on T2-weighted images with a twofold reduction in T2 relaxation time compare to unconjugates. Conclusion: EGRF-targeted drug delivery system could be a promising technique for increasing the effectiveness of drugs in cancer therapy with a lower side effects.

Key words: Epidermal growth factor receptor, Cancers, Nanoparticle drug delivery