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Background: Uric acid is the end product in metabolism process of purine, a component of nucleic acid found in cell nucleus. Recently, there are many commercial Point-of-care test (POCT) devices for swamonitoring-blood uric acid. Objective: The study aimed to determine the validity and reliability of POCT and the effect of time and sampling location compared to the results measurement. Methods: The study was conducted using 3 different POCT devices and 10 healthy volunteers, consist of 5 men and 5 women. Validity study was carried out by measuring uric acid level in blood from vein and capillary vessels using 3 different POCT devices compared to clinical laboratory test. Reliability study was carried out by measuring uric acid level taken from capillary vessel for 14 times, in the morning and evening, for 7 consecutive days. The effect of sampling location was studied by measuring and comparing uric acid level in samples taken from both right and left hands of each subject. Results: Validity study showed that only one of three brands which has valid statistically proven with t-test result (p ≤ 0.05). Range of measurement uric acid level using POCT devices is 3.00-10.80 mg/dl.  Only 2 brands were proven statistically reliable with the value of Cronbach's alpha 0.653 and 0.688. The measurement of uric acid level using POCT devices gave the best result when sample was taken in the morning. Sampling location does not significantly affect blood uric acid level measurement, statistically proven with t-test result (p ≤ 0.05). Conclusion: Rapid blood uric acid measurement using POCT devices were proven valid only one brands, the best time of measurement uric acid level in the morning and sampling location does not significantly affect blood uric acid level measurement.