Universitas Indonesia Conferences, Asian Federation for Pharmaceutical Sciences (AFPS) 2019

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The Effect of Lipid Ratio on Physical Characteristics of Resveratrol loaded Nanostructured Lipid Carrier
Dita Nurlita Rakhma

Last modified: 2019-07-20


Abstract: Solid Lipid nanoparticle (SLN) has the advantage of delivering lipophilic compounds such as Resveratrol (RSV) for dermal application. The use of binary solid lipids Glyceryl Monostearate (GMS) and beeswax in SLN have been known to improve drug loading, but SLN tends to recrystallize during storage, which leads to the leakage of active compounds. It is necessary to develop a Nanostructured Lipid Carrier (NLC) delivery system to overcome this problem. Objective: This study aimed to determine the effect of lipid ratio on the physical characteristics of RSV-loaded NLC. Material and Methods: NLC was prepared by high shear homogenization method using binary solid lipids GMS and Beeswax, oil lipid Medium Chain Triglycerides (MCT) at the ratio of 10:0, 5:5, 4:6, and 2.5:7.5. Differential scanning calorimetry (DSC), transmission electron microscopy (TEM), particle size (PS), polydispersity index (PI), pH and entrapment efficiency (EE) determination observed. Results: The lipid ratio of 2.5: 7.5  has the lowest PS (210.7 ± 18.2 nm), the lowest PI (0,186±0,082) and the highest EE (92,0±0,01%) showed by 4:6 ratio, a 10:0 ratio has more spherical morphology than 2.5:7.5. Conclusion: Based on these results, the lipid ratio affects the physical characteristics of the RSV-loaded NLC system.