Universitas Indonesia Conferences, Asian Federation for Pharmaceutical Sciences (AFPS) 2019

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Safety and Efficacy Evaluation on Combination of Gardenia Jasminoides Flower and Leaves Extract as Moisturizer Agent for Cosmetic
Yogo Suro Priyadi

Last modified: 2019-06-15


Gardenia jasminoides leaf and flower extract were evaluated for skin moisturizing activity. A randomized double-blind controlled clinical trial was conducted to evaluated moisturizing effect of lotion contain Gardenia extracts. Result showed effectivity through significant improvement in skin hydration in comparison with well known moisturizing active ingredient. The possible mechanism is that the gardenia extracts hydrate skin via the humectants and hydrocolloids. Prior to this in vivo efficacy study, safety evaluation was conducted using Single Closed Patch Test (SCPT) for skin and Hen's Egg Test – Chorioallantoic Membrane (HET-CAM) to evaluate the irritation at ocular level. Furthermore, safety evaluation of the lotion by SCPT and HET-CAM showed that it can be used safely for human skin and eyes. For commercial applications, the physicochemical characteristics of the test products, including Hunter L, a, and b values; pH; refractive index; and coefficient of viscosity were evaluated. Gardenia extract did not affect overall formulations of the test cream product in any of the tested aspects. These results suggest that Gardenia extract is a promising ingredient in moisturizing formulations and proven to be safe and effective in cosmetic