ABSTRACT

Background: Epithelialization process is an indicator of wound healing. Platelet-rich plasma (PRP) may accelerate epithelialization due to its content of growth factors. Generally, allogeneic platelet rich plasma (PRP) provides a smaller immunological effect than autologous PRP. The aim of this study was to investigate the effect of allogeneic freeze-dried platelet rich plasma on wound healing of full thickness wound in New Zealand rabbit. Method: 2x2 cm² full-thickness wounds were created on rabbits using a template on two sides on the dorsum and divided into two groups. The first group was treated with allogeneic freeze dried PRP as treatment group, and the second group was treated with moist dressing or tulle as control group. Acceleration of wound healing was shown by the epithelialization and measured on day seven by digital visitrak. Result: Nine New Zealand rabbits enrolled this study. In the treatment group, the epithelialization was significantly higher 3.00 ± 0.96 cm² than the control group 1.35 ± 0.85 cm² (p <0.000) by independent t-test. The result was also shown that the allergic reaction was not observed during this the administration of allogeneic freeze-dried PRP. Conclusion: Allogeneic freeze dried PRP stimulates the epithelialization process and does not cause an allergic reaction in full thickness wounds in rabbits.

Keyword : Allogenic, freeze dried PRP, full thickness wound, ephitelialization