Sterculia rubiginosa Zoll. Ex Miq is traditionally used to treat asthma. Allergy is one of the causes of asthma. This study aims to determine the activity of Sterculia rubiginosa extract as an allergy by inhibiting active cutaneous anaphylactic reactions. This study used an active cutaneous anaphylaxis method. This study used  24 Balb / C mice which divided into six groups. Mice were sensitized with ovalbumin in a 0.1% Al (OH) 3 concentration subcutaneously two times with an interval of 7 days. The back of the mice shaved and injected with Evans blue intravenously on the mice tail. After the second sensation was carried out, treated with normal controls, negative controls (Na-CMC 0.5%), positive controls (cetirizine 0.042 mg / 20 g BB), n-hexane extract dosage 50 mg / 20 g BB, ethyl acetate extract 50 mg / 20 g BB, and methanol extract 50 mg / 20 g BB. The reaction generation using ovalbumin in the suspension of Al(OH)₃ 0.52%. Bentleys (pigmented areas) are measured every hour for 8 hours then calculated AUC_0-8. The statistical analysis with One way ANOVA test results (ρ <0.05) followed by the Tukey test. The result showed that n-hexane, ethyl acetate and methanol extract at a dose of 50 mg/20 g BB, had anti-allergic activity against active cutaneous anaphylactic response. The percentage of active cutaneous anti-anaphylactic power was ethyl acetate extract 45.42%, methanol extracts 39.94% and n-hexane extract 31.68%, and for cetirizine positive control 62.29%. Methanol extract has hypo-allergenic activity as same as n-hexane extract (ρ> 0.05).